Statistical Summary

2024 Summary of Donor Screening Activities

Row

2024 Leukopak Collections

74

2024 PanT Isolations

75

2024 AlloBCMA CAR-T Productions

78

2024 CAR-T Donor Expanders

66

2024 CAR-T Donors Tested in-vivo

62

2024 CAR-T Donors Controlling Tumor

51

2024 Donor Expander Rate

2024 In-Vivo Control Rate

2024 Validated Donor Rate

Row

Leukopak Collections by Year

PanT Isolations by Year

CAR-T Productions by Year

CAR-Ts Dosed by Year

### Sankey Diagrams

2024

2023

2022

Donor Screening Database Table

Rows

Donor Screening Database

Production Fold-Expansion

Column

Production Fold-Expansion Distribution

Column

Expansion Spearman Correlations

Expansion Pearson Correlations

Ranked Cross Correlation (Pearson)

Column

CO2

Aph Tcells

Aph NKcells

Aph Tcells-CD4

Aph Tcells-CD8

PanT Tcells

PanT NKcells

PanT Monocytes

PanT CD4-Naive

PanT CD4-Naive-Tscm

PanT CD4-CCR7

PanT CD4-CD62L

PanT CD4-Tem

PanT CD8-Naive-Tscm

PanT CD8-CCR7

PanT CD8-CD62L

PanT CD8-Tem

PanT CD8-Teff

PanT CD4-CD27

PanT CD4-Lag3

PanT CD4-Tim3

PanT CD8-CD25

PanT CD8-Lag3

PanT PostThaw CD4-CD25

PanT PostThaw CD4-CXCR3

Categories vs Fold-Expansion

Column

This is a figure

Column

Blood Source

Fresh vs Frozen LKPK

Type of Material

Sex

Ethnicity

Smoker Status

Blood Type

CMV Status

HHV7 NAT

Production Department

Nucleofector Used

CD2 Booster

SpB Version

Column

Blood Source

# A tibble: 6 × 8
  .y.                   group1   group2         p p.adj p.format p.signif method
  <chr>                 <chr>    <chr>      <dbl> <dbl> <chr>    <chr>    <chr> 
1 Harvest.FoldExpansion AllCells OBI       0.688   1    0.688    ns       Wilco…
2 Harvest.FoldExpansion AllCells Hemacare  0.0728  0.29 0.073    ns       Wilco…
3 Harvest.FoldExpansion AllCells StemExpr… 0.0260  0.16 0.026    *        Wilco…
4 Harvest.FoldExpansion OBI      Hemacare  0.0865  0.29 0.086    ns       Wilco…
5 Harvest.FoldExpansion OBI      StemExpr… 0.0306  0.16 0.031    *        Wilco…
6 Harvest.FoldExpansion Hemacare StemExpr… 0.769   1    0.769    ns       Wilco…

Fresh vs Frozen

# A tibble: 1 × 8
  .y.                   group1 group2      p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion Fresh  Frozen 0.0253 0.025 0.025    *        Wilcoxon

Type of Material

# A tibble: 1 × 8
  .y.                   group1 group2      p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion LKPK   PBMC   0.0244 0.024 0.024    *        Wilcoxon

Sex

# A tibble: 1 × 8
  .y.                   group1 group2      p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion F      M      0.0692 0.069 0.069    ns       Wilcoxon

Ethnicity

# A tibble: 28 × 8
   .y.                   group1     group2      p p.adj p.format p.signif method
   <chr>                 <chr>      <chr>   <dbl> <dbl> <chr>    <chr>    <chr> 
 1 Harvest.FoldExpansion Hispanic/… Asian  1       1    1.0000   ns       Wilco…
 2 Harvest.FoldExpansion Hispanic/… Nativ… 0.940   1    0.9399   ns       Wilco…
 3 Harvest.FoldExpansion Hispanic/… Other  0.498   1    0.4979   ns       Wilco…
 4 Harvest.FoldExpansion Hispanic/… Cauca… 0.314   1    0.3144   ns       Wilco…
 5 Harvest.FoldExpansion Hispanic/… Multi… 0.106   1    0.1063   ns       Wilco…
 6 Harvest.FoldExpansion Hispanic/… Afric… 0.0618  1    0.0618   ns       Wilco…
 7 Harvest.FoldExpansion Hispanic/… Hispa… 0.0327  0.69 0.0327   *        Wilco…
 8 Harvest.FoldExpansion Asian      Nativ… 0.963   1    0.9626   ns       Wilco…
 9 Harvest.FoldExpansion Asian      Other  0.347   1    0.3471   ns       Wilco…
10 Harvest.FoldExpansion Asian      Cauca… 0.147   1    0.1472   ns       Wilco…
# ℹ 18 more rows

Smoker Status

# A tibble: 1 × 8
  .y.                   group1 group2     p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>  <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion N      Y      0.388  0.39 0.39     ns       Wilcoxon

Blood Type

# A tibble: 15 × 8
   .y.                   group1 group2      p p.adj p.format p.signif method  
   <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
 1 Harvest.FoldExpansion O-     AB+    0.368   1    0.368    ns       Wilcoxon
 2 Harvest.FoldExpansion O-     A+     0.217   1    0.217    ns       Wilcoxon
 3 Harvest.FoldExpansion O-     B+     0.197   1    0.197    ns       Wilcoxon
 4 Harvest.FoldExpansion O-     O+     0.233   1    0.233    ns       Wilcoxon
 5 Harvest.FoldExpansion O-     A-     0.0203  0.26 0.020    *        Wilcoxon
 6 Harvest.FoldExpansion AB+    A+     0.772   1    0.772    ns       Wilcoxon
 7 Harvest.FoldExpansion AB+    B+     0.680   1    0.680    ns       Wilcoxon
 8 Harvest.FoldExpansion AB+    O+     0.735   1    0.735    ns       Wilcoxon
 9 Harvest.FoldExpansion AB+    A-     0.0324  0.36 0.032    *        Wilcoxon
10 Harvest.FoldExpansion A+     B+     0.955   1    0.955    ns       Wilcoxon
11 Harvest.FoldExpansion A+     O+     0.959   1    0.959    ns       Wilcoxon
12 Harvest.FoldExpansion A+     A-     0.0108  0.16 0.011    *        Wilcoxon
13 Harvest.FoldExpansion B+     O+     0.904   1    0.904    ns       Wilcoxon
14 Harvest.FoldExpansion B+     A-     0.0249  0.3  0.025    *        Wilcoxon
15 Harvest.FoldExpansion O+     A-     0.0176  0.25 0.018    *        Wilcoxon

CMV Status

# A tibble: 1 × 8
  .y.                   group1 group2     p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>  <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion Y      N      0.728  0.73 0.73     ns       Wilcoxon

HHV7 NAT

# A tibble: 1 × 8
  .y.                   group1 group2     p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>  <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion N      Y      0.530  0.53 0.53     ns       Wilcoxon

Production Department

# A tibble: 3 × 8
  .y.                   group1 group2      p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion IO     MSAT   0.0268 0.054 0.027    *        Wilcoxon
2 Harvest.FoldExpansion IO     Wuxi   0.0133 0.04  0.013    *        Wilcoxon
3 Harvest.FoldExpansion MSAT   Wuxi   0.202  0.2   0.202    ns       Wilcoxon

Nucleofector Used

# A tibble: 10 × 8
   .y.                   group1  group2       p   p.adj p.format p.signif method
   <chr>                 <chr>   <chr>    <dbl>   <dbl> <chr>    <chr>    <chr> 
 1 Harvest.FoldExpansion Edison  Joule  6.64e-1 6.6 e-1 0.66423  ns       Wilco…
 2 Harvest.FoldExpansion Edison  Frank… 8.71e-6 6.1 e-5 8.7e-06  ****     Wilco…
 3 Harvest.FoldExpansion Edison  Volta  1.66e-6 1.7 e-5 1.7e-06  ****     Wilco…
 4 Harvest.FoldExpansion Edison  Farad… 5.98e-6 4.80e-5 6.0e-06  ****     Wilco…
 5 Harvest.FoldExpansion Joule   Frank… 4.05e-3 1.2 e-2 0.00405  **       Wilco…
 6 Harvest.FoldExpansion Joule   Volta  1.12e-3 4.5 e-3 0.00112  **       Wilco…
 7 Harvest.FoldExpansion Joule   Farad… 3.98e-4 2.4 e-3 0.00040  ***      Wilco…
 8 Harvest.FoldExpansion Frankl… Volta  1.32e-2 2.6 e-2 0.01323  *        Wilco…
 9 Harvest.FoldExpansion Frankl… Farad… 1.73e-6 1.7 e-5 1.7e-06  ****     Wilco…
10 Harvest.FoldExpansion Volta   Farad… 7.72e-4 3.9 e-3 0.00077  ***      Wilco…

CD2 Booster

# A tibble: 3 × 8
  .y.                   group1 group2      p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>   <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion v2     v1     0.856  0.86  0.856    ns       Wilcoxon
2 Harvest.FoldExpansion v2     v2 COD 0.0239 0.072 0.024    *        Wilcoxon
3 Harvest.FoldExpansion v1     v2 COD 0.344  0.69  0.344    ns       Wilcoxon

SPB version

# A tibble: 1 × 8
  .y.                   group1 group2     p p.adj p.format p.signif method  
  <chr>                 <chr>  <chr>  <dbl> <dbl> <chr>    <chr>    <chr>   
1 Harvest.FoldExpansion v2     v3     0.838  0.84 0.84     ns       Wilcoxon

In-Vitro Assays to 5e6 Dose

Rows

Tumor Control at 5e6 Dose Distribution

In-vitro Assays to 5e6 dose

Rows

0hrsPostthaw AV/PI

24hrPostThaw AV/PI

48hrsPostthaw AV/PI

Row

0hrsPostthaw Luna

24hrsPostthaw Luna

48hrsPostthaw Luna

Row

24hrsPostThaw NC200

48hrsPostThaw NC200

24hrsPostThaw LateApoptotic

48hrsPostThaw LateApoptotic

Rows

Cytotoxicity 5:1 E:T ratio

Cytotoxicity 10:1 E:T ratio

Luciferase Cytotoxicity EC:50

Serial Restim Cytotoxicity EC50

Row

CD127 of CD4

CD127 of CD4

Tscm of CD4

Tscm of CD8

Row

PD1 of CD4

PD1 of CD8

Tim3 of CD8

In-Vitro Assays to 2.5e6 Dose

Rows

Tumor Control at 2.5e6 Dose Distribution

In-Vitro Assays to 2.5e6 dose

Rows

0hrsPostthaw Luna

24hrsPostthaw Luna

48hrsPostthaw Luna

24hrPostThaw AV/PI

Rows

0hrsPostThaw LateApoptotic

24hrsPostThaw LateApoptotic

48hrsPostThaw Necrotic

48hrsPostThaw Early Apoptotic

Rows

Cytotoxicity 5:1 E:T ratio

Cytotoxicity 10:1 E:T ratio

Luciferase Cytotoxicity EC:50

Row

CD127 of CD4

CD127 of CD8

Tscm of CD4

Tscm of CD8

Row

PD1 of CD4

PD1 of CD8

Lag3 of CD4

Lag3 of CD8

CD4-CD8 focus

Row

Row

Row