Overview

Donor Screening Database

The Donor Screening database is a collection of data sets joined together using a donor’s Donor number, Donor ID (Lot number), and Production experiment.

The database consists of:

• Donor Basic information
  • Sex, Age, Ethnicity, Weight/Height/BMI, Blood Type, Smoker Status
  • Viral Tests: CMV, HHV6, HHV7.AB, HHV7.NAT
  • HLA information
• Metabolic information
  • Glucose, eGFR, CO2, Calcium, Albumin, Globulin, Bilirubin, AST, ALT, etc.
• Phenotyping Information
  • Apheresis, PanT, and Post-thaw PanT
  • Purity, Memory, Activation, Exhaustion, and Traffic Markers
• CAR-T Production Data
  • Reagents, Nucleofectors
  • Gene Transposition/KO, Fold-Expansion Kinetics
  • Phenotyping
• CAR-T Invitro Assays
  • Health and Viability Assays
  • Cytotoxicity/Serial Restimulation
  • CAR Expression
  • Phenotyping (Memory, Activation/Exhaustion, Traffic Markers)
• CAR-T Invivo Assays
  • RPMI-8226 mouse model
  • 5e6 and 2.5e6 doses
  • Tumor Volume/Control normalized to untreated

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